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Oesophageal cancer 10-minute sponge trial starts

University of Cambridge Prof Rebecca Fitzgerald in the background, wearing a mauve jacket over a purple top and with a surgical mask on. She is holding in the foreground a black sponge in her right hand which has a string attachedUniversity of Cambridge
The sponge is a "remarkable innovation by Prof Rebecca Fitzgerald [above] and her team", according to Michelle Mitchell, chief executive of Cancer Research UK

People who regularly take medication for heartburn will be invited to join the final stage of an oesophageal cancer screening trial using a 10-minute sponge test.

Patients will be asked to swallow a dissolvable pill on a string, which releases a sponge the size of a 50p coin to collect cells from the oesophagus as it is retrieved. If successful, it could become part of the UK NHS cancer screening programme.

Prof Rebecca Fitzgerald, from the University of Cambridge, said: "Catching [cancer] earlier can save lives by reducing the need for chemotherapy and surgery to remove the oesophagus."

The £6.4m project, which hopes to recruit 120,000 people, is jointly funded by Cancer Research UK and the National Institute for Health and Care Research.

University of Cambridge Prof Rebecca Fitzgerald sitting in front of two shelves packed with books and files. She has short dark curling hair, is wearing a blue top and is smiling University of Cambridge
It follows decades of research by the professor and a team of scientists, clinicians and nurses who invented and refined the capsule sponge test

Oesophageal cancer is found anywhere in the oesophagus, sometimes called the gullet or food pipe.

The capsule sponge, known as the pill-on-a-thread, is a quick and simple test for Barrett's oesophagus, a condition that can be a precursor to cancer.

The sponge is swallowed, its coating dissolves when it reaches the stomach and it is then carefully pulled back up using the string, collecting cells for laboratory testing.

Paul Anderson, 59, a stock controller from St Neots, Cambridgeshire, was one of the trial's first participants.

He hoped it will "give me some more insight into my chronic heartburn, as well as helping people who may have similar concerns about their health".

EMS Healthcare Five large white camper vans in front of a grey and orange building saying EMS. One of the vans is side on and it has pink writing saying heartburn health and do you experience heartburn, indigestion or acid reflux?EMS Healthcare
Mobile screening vans will be rolled out across England to deliver the tests, which will take a nurse 10 minutes

Prof Fitzgerald, director of the university's Early Cancer Institute, said the method is "changing how we detect Barrett's oesophagus and oesophageal cancer".

It was hoped the test could save lives and reduce the need for "labour-intensive" endoscopy - a camera down the throat - which is currently the "gold standard" to diagnose and treat this type of cancer, according to Cancer Research UK.

It said there were about 9,300 new cases of oesophageal cancer in the UK every year, making it the seventh most common cause of cancer death in the country.

The BEST4 Screening trial is open to men over 55 and women over 65 who were already taking medication for chronic heartburn, with invitations to be sent by text message from the NHS.

The research is led by Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge.

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